Related Experiment Video
Updated: Jun 28, 2026
Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
Published on: January 17, 2018
Intracranial phosphaturic mesenchymal tumor: A rare case report and systematic review
Shuyue Song1, Yuyang Zhao1, Yiquan Wang1
1School of Clinical Medicine, Shandong Second Medical University, Weifang, China.
Rationale:
Phosphaturic mesenchymal tumors (PMTs) are rare soft-tissue and bone tumors that can occur intracranially. Low incidence, nonspecific symptoms, and diverse histomorphology of PMTs contribute to a high rate of misdiagnosis.
Patient Concerns:
This report presents a rare case of an intracranial PMT located in the posterior cranial fossa. In addition, a systematic review of previously reported intracranial PMT cases was conducted and summarized.
Diagnoses:
Incorporating clinical symptoms, laboratory findings, and imaging features, the definitive diagnosis of PMT was based on pathological examination.
Interventions:
The patient underwent consultations in endocrinology, orthopedics, and neurosurgery, and ultimately had a surgical procedure to remove the intracranial tumor.
Outcomes:
After tumor resection, the patient's laboratory values returned to normal, his symptoms improved, and he could walk again.
Lessons:
Due to the rarity and high misdiagnosis rate of PMTs, no unified diagnosis and treatment standards have been established. Early identification, accurate diagnosis, and timely treatment are essential for optimal management. Surgical resection remains the preferred treatment for PMTs, with total tumor resection strongly recommended. In case of incomplete resection, tumor recurrence and persistent symptoms may necessitate adjunctive drug therapy and radiation therapy.
Insights
Phosphaturic mesenchymal tumors (PMTs) are rare intracranial tumors often misdiagnosed. Early diagnosis and surgical resection are crucial for successful treatment and symptom resolution.
Area of Science:
- Neurosurgery
- Oncology
- Pathology
Background:
- Phosphaturic mesenchymal tumors (PMTs) are rare neoplasms with potential intracranial involvement.
- Their low incidence, nonspecific symptoms, and varied appearance lead to frequent misdiagnosis.
Purpose of the Study:
- To report a rare case of an intracranial PMT in the posterior cranial fossa.
- To systematically review and summarize existing literature on intracranial PMTs.
Main Methods:
- Diagnosis was confirmed through pathological examination, integrating clinical, laboratory, and imaging data.
- A systematic literature review was performed to gather data on previously reported cases.
Main Results:
- The patient underwent multidisciplinary consultations and surgical tumor resection.
- Post-surgery, the patient experienced normalized laboratory values, symptom improvement, and regained mobility.
Conclusions:
- Established diagnostic and treatment standards for PMTs are lacking due to their rarity.
- Prompt identification, accurate diagnosis, and complete surgical resection are vital for optimal outcomes.
- Adjuvant therapies may be necessary for incomplete resections to manage recurrence and persistent symptoms.
Related Concept Videos
02:21Cancers Originate from Somatic Mutations in a Single Cell
02:21Cancers Originate from Somatic Mutations in a Single Cell