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Chronic pharyngitis and cervical spondylosis risk: A bidirectional Mendelian randomization study
Yuwei Li1, Xiaoxi Li2, Xinya Yu1
1Department of Medical Microbiology and Immunology, School of Basic Medical Sciences, Dali University, Dali, Yunnan, P.R. China.
Medicine
|February 24, 2025
Summary
Chronic pharyngitis (CP) may increase the risk of developing cervical spondylosis (CS). This study used Mendelian randomization to analyze the causal link, finding CP is a risk factor for CS.
Area of Science:
- Epidemiology
- Genetics
Background:
- Cervical spondylosis (CS) is a common degenerative condition in older adults.
- A potential link between chronic pharyngitis (CP) and CS has been suggested but not established.
Purpose of the Study:
- To investigate the causal relationship between chronic pharyngitis and cervical spondylosis using a bidirectional Mendelian randomization analysis.
Main Methods:
- Genome-wide association study data were used to identify single nucleotide polymorphisms as instrumental variables for CP and CS.
- Bidirectional Mendelian randomization analysis was performed.
- Sensitivity analyses including IVW, weighted median, and MR-Egger regression were conducted to ensure robustness.
Main Results:
- The analysis indicated that chronic pharyngitis significantly influences the risk of developing cervical spondylosis (IVW OR: 1.183, P < .001).
- The reverse causation, where CS impacts CP incidence, was not strongly supported by the analyses (IVW OR: 1.083, P = .009).
Conclusions:
- Chronic pharyngitis is suggested as a potential risk factor for cervical spondylosis.
- Further research may explore therapeutic strategies targeting CP to mitigate CS risk.
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