Investigating casual association among gut microbiome and esophageal cancer: A Mendelian randomization study

The gut microbiota has been strongly linked to gastrointestinal cancer, but the relationship between gut microbiota and esophageal cancer (EC) is still not fully understood. We conducted a 2-sample Mendelian randomization (MR) study to unveil the potential impact of intestinal microorganisms on EC in East Asian populations. In order to delve deeper into the potential causal relationship between gut microbiota and EC, we conducted a 2-sample MR analysis, utilizing 211 single nucleotide polymorphisms associated with gut microbiota, sourced from the largest genome-wide association study on gut microbiota, for our analysis. To estimate the causal relationship, we employed the inverse variance weighting method. In addition, to assess the potential influence of pleiotropy, we used MR-Egger regression in our analysis. Among the 10 specific bacterial taxa identified using the inverse variance weighting as being associated with the risk of EC, we observed a positive association between family Bacteroidaceae (P = .04), genus Bacteroides (P = .04), genus Bilophila (P = .02), genus Candidatus Soleaferrea (P = .02) and the EC, while family Victivallaceae (P = .03), genus Eubacterium coprostanoligenes (P = .01), genus Catenibacterium (P = .01), genus Coprococcus2 (P = .01), unknowngenus.id.959 (P = .02) and unknowngenus.id.1868 (P = .01) may be associated with a reduced risk of EC. Our MR analysis indicate a probable association between gut microbiota and the development and advancement of EC. These findings offer novel perspectives on the possible application of targeted gut bacteria for the prevention and management of EC.