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Related Concept Videos

Plastic Deformations of Members with a Single Plane of Symmetry01:21

Plastic Deformations of Members with a Single Plane of Symmetry

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When a structural member undergoes plastic deformation due to bending, it is crucial to understand the position of the neutral axis and the stress distribution. This member, characterized by a single plane of symmetry, exhibits a uniform stress distribution, with negative stress above the neutral axis and positive stress below. Notably, the neutral axis does not align with the centroid of the cross-section. This misalignment is typical in cases where the cross-section is not rectangular or...
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Related Experiment Video

Updated: May 26, 2025

Multi-Scale Modification of Metallic Implants With Pore Gradients, Polyelectrolytes and Their Indirect Monitoring In vivo
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Designing Positionally Stable Smooth Breast Implants.

Tim Y Li1, Sophia Salingaros1, Hector F Salazar1

  • 1Laboratory of Bioregenerative Medicine and Surgery, Division of Plastic Surgery, Weill Cornell Medicine, New York, New York 10065, United States.

ACS Biomaterials Science & Engineering
|February 24, 2025
PubMed
Summary
This summary is machine-generated.

A new smooth breast implant with surface wells (PSSI) offers stability comparable to textured implants. This design reduces inflammation and may provide a safer alternative to textured devices.

Keywords:
BIA-ALCLbreast implantsbreast reconstructionpositional stability

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Area of Science:

  • Biomaterials Science
  • Plastic Surgery
  • Regenerative Medicine

Background:

  • Textured breast implants, previously favored for stability, have been recalled due to links with Breast Implant-Associated Anaplastic Large Cell Lymphoma.
  • This recall necessitates alternative solutions for achieving breast implant positional stability.
  • A novel Positionally Stable Smooth Implant (PSSI) with surface wells has been engineered to promote capsule ingrowth and device stabilization.

Purpose of the Study:

  • To assess the long-term *in vivo* positional stability of PSSI designs.
  • To characterize capsule formation and inflammatory response around PSSI.
  • To compare PSSI performance against traditional smooth and textured implants.

Main Methods:

  • Miniature poly(dimethylsiloxane) implants, including PSSI with varied well dimensions, were tested.
  • Implants were surgically placed in Sprague-Dawley rats, with rotation monitored via MicroCT over 8 weeks.
  • Explanted implant-capsule units underwent histological analysis at 3 months.

Main Results:

  • PSSI demonstrated significantly reduced cumulative rotation compared to smooth implants, achieving stability comparable to textured implants.
  • MicroCT and gross examination confirmed substantial capsule ingrowth within the PSSI wells.
  • Histology revealed fewer pro-inflammatory M1 macrophages and reduced myofibroblast expression in PSSI capsules versus controls.

Conclusions:

  • The novel PSSI design successfully achieves positional stability comparable to textured implants.
  • PSSI elicits a reduced pro-inflammatory response and lower myofibroblast expression than traditional smooth implants.
  • These findings suggest PSSI represents a promising and potentially safer alternative to textured breast implants.