Related Experiment Video

Updated: Jun 14, 2025

Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells
10:06

Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells

Published on: April 26, 2017

8.9K

Overview of splicing variation in ovarian cancer

Min Zhou1, Mengdie Tian1, Zhuoer Li1

  • 1From the Department of Gynecology and Obstetrics, Shengjing Hospital of China Medical University, Shenyang, China.

Biochimica Et Biophysica Acta. Reviews on Cancer
|February 24, 2025
PubMed

Insights

Aberrant splicing variants in ovarian cancer are key to understanding disease progression and treatment resistance. Targeting these splicing events offers new hope for developing diagnostic biomarkers and effective therapies.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Ovarian cancer has a high mortality rate despite immunotherapy advancements.
  • Aberrant splicing significantly contributes to cancer heterogeneity and treatment resistance.
  • Splicing variants, particularly involving BRCA1/2, impact disease progression and patient outcomes.

Purpose of the Study:

  • To review the role of splicing variants in ovarian cancer.
  • To emphasize their involvement in metastasis and treatment resistance.
  • To provide insights for biomarker development and novel therapeutic strategies.

Main Methods:

  • Literature review of studies on splicing variants in ovarian cancer.
  • Analysis of the clinical significance of splicing variants and factors.
  • Synthesis of current research on splicing's role in ovarian cancer progression and resistance.

Main Results:

  • Aberrant splicing is a critical factor in ovarian cancer heterogeneity.
  • Specific splicing variants are linked to metastasis and resistance to therapies.
  • Splicing factors and variants show potential as biomarkers and therapeutic targets.

Conclusions:

  • Splicing variants are crucial in ovarian cancer development and progression.
  • Understanding these variants can lead to improved diagnostic and prognostic tools.
  • Targeting splicing mechanisms presents a promising avenue for future ovarian cancer treatments.
Keywords:
Alternative splicingOvarian cancerSplicing variants

More Related Videos

Using RNA-sequencing to Detect Novel Splice Variants Related to Drug Resistance in In Vitro Cancer Models09:58

Using RNA-sequencing to Detect Novel Splice Variants Related to Drug Resistance in In Vitro Cancer Models

Published on: December 9, 2016

13.7K
Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts10:27

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts

Published on: July 25, 2020

7.2K

Related Concept Videos

RNA Splicing01:32

RNA Splicing

Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
56.2K
Alternative RNA Splicing02:18

Alternative RNA Splicing

Alternative RNA splicing is the regulated splicing of exons and introns to produce different mature mRNAs from a single pre-mRNA. Unlike in constitutive splicing where a single gene produces a single type of mRNA, alternative splicing allows an organism to produce multiple proteins from a single gene and plays an important role in protein diversity.
There are five types of alternative RNA splicing that vary in the ways the pre-mRNA segments are removed or retained in the mature mRNA. The first...
21.1K
Pre-mRNA Processing: RNA Splicing01:36

Pre-mRNA Processing: RNA Splicing

5.2K
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
7.3K
Long-patch Base Excision Repair01:02

Long-patch Base Excision Repair

Since the discovery of the two BER pathways, there has been a debate about how a cell chooses one pathway over the other and the factors determining this selection. Numerous in vitro experiments have pointed out multiple determinants for the sub-pathway selection. These are:
7.0K
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.3K