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Aberrant miRNA expression and protein arginine methyltransferase 5 (PRMT5) in cancer: A review

Saïd Sif1, Majdi Al Alawneh1

  • 1Department of Biological and Environmental Sciences, College of Arts and Sciences, Qatar University, Doha, Qatar.

Biochimica Et Biophysica Acta. Molecular Cell Research
|February 24, 2025
PubMed

Insights

Protein arginine methyltransferase 5 (PRMT5) epigenetic silencing and circular PRMT5 RNA (circ-PRMT5) promote cancer cell growth. Understanding their interplay with tumor suppressor miRNAs is crucial for cancer therapy development.

Area of Science:

  • Molecular Biology
  • Epigenetics
  • Cancer Research

Background:

  • Cancer cell growth and survival involve complex molecular interactions.
  • Key players include transcription factors, epigenetic modifiers, and miRNAs.
  • The interplay between these factors, especially PRMT5, in tumorigenesis is not fully understood.

Purpose of the Study:

  • To review the role of PRMT5-mediated epigenetic silencing in cancer.
  • To explore the function of tumor suppressor miRNAs regulated by PRMT5.
  • To elucidate the mechanisms of circ-PRMT5 in promoting cancer cell proliferation and survival.

Main Methods:

  • Literature review focusing on PRMT5, epigenetic silencing, miRNAs, and circRNAs.
  • Analysis of existing studies on PRMT5 and its targets.
  • Synthesis of current knowledge on circ-PRMT5 functions in cancer.

Main Results:

  • PRMT5 plays a significant role in epigenetic silencing, contributing to cancer progression.
  • PRMT5 regulates tumor suppressor miRNAs, impacting cancer cell fate.
  • Circular PRMT5 RNA (circ-PRMT5) actively promotes cancer cell proliferation and survival.

Conclusions:

  • PRMT5-mediated epigenetic silencing and circ-PRMT5 are critical drivers of tumorigenesis.
  • Targeting PRMT5 and circ-PRMT5, alongside miRNA regulation, offers potential therapeutic strategies.
  • Further research into the crosstalk between PRMT5, miRNAs, and circRNAs is warranted for comprehensive cancer treatment approaches.
Keywords:
GlioblastomaPI3K/AKT signalingProtein arginine methyltransferase 5Tumor suppressor miRNAWNT/β-CATENIN signaling

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