Progress of extracellular vesicles-based system for tumor therapy

Area of Science:

• Biomedical Engineering
• Nanotechnology
• Oncology

Background:

• Rising global cancer incidence necessitates innovative therapeutic strategies.
• Extracellular vesicles (EVs) are crucial nano-sized mediators of intercellular communication.
• EVs possess inherent properties making them suitable for therapeutic applications.

Purpose of the Study:

• To review the current state of extracellular vesicle (EV)-based tumor treatment methods.
• To discuss the sources, functions, and applications of EVs in cancer therapy.
• To explore the potential of artificial EVs compared to natural EVs.

Main Methods:

• Literature review of recent research on EV-based anti-tumor treatments.
• Analysis of EV characteristics, functions, and therapeutic applications.
• Comparison of natural and artificial EVs for tumor treatment.

Main Results:

• Diverse EVs from various sources exhibit unique properties for anti-tumor applications.
• EVs are effective drug and vaccine delivery carriers, showing satisfactory results in preclinical studies.
• Clinical trials for EV-based tumor therapy are ongoing, demonstrating therapeutic potential.

Conclusions:

• EVs represent a promising platform for developing novel anti-tumor treatments.
• Artificial EVs offer unique advantages over natural EVs for targeted cancer therapy.
• Further research and development are crucial to accelerate the clinical translation of EV-based cancer therapies.