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Correlation Between Skeletal Muscle Mass and Different Pathological Types of Colorectal Polyp in Chinese Asymptomatic Population

  • 0Ultrasound Department, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People's Republic of China.
International Journal of General Medicine +

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February 25, 2025

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February 25, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

Low skeletal muscle mass index (SMI) is linked to a reduced risk of inflammatory polyps, particularly in asymptomatic Chinese males. Higher SMI was associated with increased occurrence of inflammatory and serrated polyps in males.

Area Of Science

  • Gastroenterology
  • Public Health
  • Epidemiology

Background

  • Previous research suggests a correlation between low relative muscle mass and an increased risk of pre-cancerous polyps (adenoma).
  • The relationship between muscle mass and various pathological types of colorectal polyps requires further investigation, especially in asymptomatic populations.

Purpose Of The Study

  • To investigate the association between skeletal muscle mass index (SMI) and the occurrence of different pathological types of colorectal polyps.
  • To explore the potential modifying effects of age and body mass index (BMI) on this relationship in a Chinese asymptomatic population.

Main Methods

  • A cohort study including 5923 asymptomatic adults.
  • Univariate and multivariate logistic regression analyses were employed to assess the effects of low SMI on colorectal polyp occurrence.
  • Analysis included stratification by polyp pathology, age, BMI, and sex.

Main Results

  • Lower SMI was significantly associated with a lower overall occurrence of colorectal polyps (OR: 0.810, p=0.015).
  • Specifically, lower SMI correlated with reduced occurrence of inflammatory polyps (OR: 0.633, p=0.013), but not conventional adenoma or serrated polyps.
  • In males, higher SMI was positively related to inflammatory polyps (OR: 1.237, p=0.007) and serrated polyps (OR: 1.288, p<0.001).
  • An interaction between BMI and SMI affected inflammatory polyp occurrence; low SMI and low BMI significantly reduced incidence (OR: 0.332, p<0.001).
  • Colorectal polyps were associated with higher SMI in males, particularly inflammatory and serrated types.

Conclusions

  • Low SMI is an independent protective factor against inflammatory and serrated polyps in asymptomatic Chinese males.
  • The findings suggest sex-specific associations between SMI and colorectal polyp subtypes.
  • Muscle mass may play a differential role in the development of various colorectal polyp pathologies.

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