Related Experiment Video
Updated: Apr 10, 2026
A Novel Rescue Technique for Difficult Intubation and Difficult Ventilation
Published on: January 18, 2011
Preoxygenation strategies before intubation in patients with acute hypoxic respiratory failure: a network
Na Ye1,2, Chen Wei2, Jiaxiang Deng2
1Department of Nursing, Fourth Affiliated Hospital of Jiangsu University, Zhenjiang, China.
Background:
Patients with acute hypoxic respiratory failure (AHRF) face life-threatening complications during tracheal intubation. Preoxygenation can enhance oxygen reserves and mitigate hypoxemia risk, but the optimal strategy remains unclear. This study aimed to identify the best preoxygenation strategy for these patients.
Methods:
We conducted a network meta-analysis of studies published up to July 2024, evaluating conventional oxygen therapy (COT), high-flow nasal cannula (HFNC), non-invasive ventilation (NIV), and their combinations prior to intubation. Data were extracted and analyzed using pairwise and network meta-analysis within a Bayesian framework. Model selection was based on the deviance information criterion (DIC).
Results:
A total of 11 randomized controlled trials involving 2,874 patients were included. NIV preoxygenation significantly reduced the likelihood of SpO2 <80% during intubation compared to COT (RR 0.28, 95% CI 0.070-0.71). No significant differences were found in lowest SpO2, complications, ICU length of stay, or mortality across preoxygenation strategies. HFNC was the most effective for reducing complications, while HFNC combined with COT or NIV showed similar effects on the lowest SpO2 during intubation.
Conclusion:
Preoxygenation with HFNC appears to be the safest and most effective approach prior to intubation in patients with AHRF compared to other strategies.
Systematic Review Registration:
PROSPERO (CRD42024565053).
More Related Videos
07:51Standardized Hemorrhagic Shock Induction Guided by Cerebral Oximetry and Extended Hemodynamic Monitoring in Pigs
Published on: May 21, 2019
07:15Preoxygenation Techniques for Tracheal Intubation in Critically Ill Adults Utilizing Oxygen Mask and Noninvasive Ventilation
Published on: December 5, 2025
Related Concept Videos
01:19Respiratory Assessment: Purpose and Indications
Objectives and Importance:
The primary goal of respiratory assessment is to evaluate patients at early risk of clinical deterioration. Since respiratory distress often precedes other signs of declining health, breathing patterns and sounds become a...
01:21Acute Respiratory Failure-II
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
01:29Acute Respiratory Failure-V
Ensure that patients are monitored continuously for their response to therapy, including changes in...
01:16Oxygen Delivering System II: Venturi Mask and Transtracheal Oxygen
Venturi Mask
The Venturi mask, named after the Venturi effect, is designed to deliver precise oxygen concentrations. It consists of a large tube with an oxygen inlet that narrows down, causing a pressure drop that pulls air in through adjustable side ports. The mask is a lightweight,...
01:17Endotracheal Intubation II: Nursing Management
1. Nursing Care of Patients Before Intubation
Before the endotracheal intubation procedure, nurses play an essential role in ensuring the process goes smoothly. The nurses must be familiar with intubation...
01:24Endotracheal Tube Extubation
Procedure
Extubation removes the endotracheal tube (ETT) from the patient on mechanical ventilation. It requires a well-coordinated, multidisciplinary approach involving physicians, nurses, respiratory therapists, and other healthcare professionals....