Drug-Induced Liver Injury Associated with Turmeric and Piperine: A Case and Review

Area of Science:

• Integrative Medicine
• Hepatology
• Pharmacovigilance

Background:

• Turmeric is widely used in traditional medicine for its health benefits.
• Enhanced bioavailability formulations, often containing piperine from black pepper, raise concerns for liver injury.
• Limited regulation of herbal supplements can lead to under-recognized adverse effects.

Purpose of the Study:

• To report a case of drug-induced liver injury (DILI) associated with turmeric and black pepper consumption.
• To emphasize the potential hepatotoxicity of herbal remedies.
• To highlight the need for further investigation into the mechanisms of turmeric-induced liver injury.

Main Methods:

• Case report of a 40-year-old female presenting with symptoms of liver injury.
• Clinical evaluation including laboratory tests and medical history review.
• Analysis of consumption of turmeric and black pepper wellness shots.

Main Results:

• The patient developed significant drug-induced liver injury.
• Symptoms included fatigue, pruritus, and dark urine.
• Consumption of turmeric and black pepper supplements was identified as the likely cause.

Conclusions:

• Herbal remedies like turmeric can be a source of hepatotoxicity.
• The safety of turmeric supplements, especially those with enhanced bioavailability, requires careful consideration.
• Further research is needed to understand the mechanisms of turmeric and black pepper hepatotoxicity and ensure safe use.