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The MRC CRASH trial at 20: Time to reappraise corticosteroids for traumatic brain injury?

Matt Thomas1, Charis Banks2, Andy Ray1

  • 1Intensive Care Medicine, North Bristol NHS Trust, Bristol, UK.

Journal of the Intensive Care Society
|February 25, 2025
PubMed
Abstract

No abstract available in PubMed .

Keywords:
Traumatic brain injurycorticosteroidsevidence based medicineneurocritical care

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DefinitionTraumatic brain injury, or TBI, is a disturbance of normal brain function induced by an external mechanical force, such as a direct blow to the head or a penetrating injury. It can affect both brain structure and function, producing a wide range of clinical outcomes. TBI is a heterogeneous condition, meaning its effects may differ based on the type, location, and severity of the injury.Basis of ClassificationTBI is classified based on severity, injury mechanism, or pathophysiology. In...