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Association of Sleep Traits, Physical Activity, and Sedentary Leisure Behavior With Female Reproductive Health: A
Jiaxin Zhang1, Tao Wang1, Pusheng Yang1
1Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, 200092, People's Republic of China.
International Journal of Women'S Health
|February 25, 2025
Summary
Insomnia is linked to endometriosis and abnormal menstruation. Longer sleep duration may protect against endometriosis, suggesting sleep habits impact female reproductive health.
Area of Science:
- Reproductive Endocrinology
- Sleep Medicine
- Genetic Epidemiology
Background:
- Female reproductive health is influenced by lifestyle factors, including sleep and physical activity.
- Adjusting living habits offers a potential avenue for promoting female reproductive well-being.
Purpose of the Study:
- To investigate the causal relationships between sleep traits, sedentary behavior, physical activity, and female reproductive health outcomes.
- To utilize a two-sample Mendelian randomization approach for robust causal inference.
Main Methods:
- Two-sample Mendelian randomization analysis using genome-wide association study summary datasets.
- Inverse-variance weighted (IVW) method as the primary analytical approach.
- Sensitivity analyses including MR-Egger, weighted median, MRE intercept, and MR-PRESSO to assess pleiotropy and heterogeneity.
Main Results:
- Insomnia showed a significant inverse causal association with endometriosis and abnormal menstruation.
- Longer sleep duration was negatively related to menopause age and showed a protective effect against endometriosis.
- Strenuous sports were negatively correlated with female infertility.
Conclusions:
- Insomnia is an adverse factor for endometriosis and abnormal menstruation.
- Adequate sleep duration and regular sleep schedules may reduce the risk of certain reproductive health issues.
- Lifestyle modifications, particularly concerning sleep, can contribute to improved female reproductive health.
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