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An Update on the Role of Lymphatic Function in Skin Inflammatory Disorders: A Scoping Review
Irina Ter-Ovanesyan1, Michelle Tashjian1, Stephanie Escruceria1
1Immunology, Nova Southeastern University Dr. Kiran C. Patel College of Osteopathic Medicine, Fort Lauderdale, USA.
Cureus
|February 25, 2025
Summary
The skin lymphatic system is crucial for health, managing inflammation, infections, and skin cancer. Proper lymphatic function supports immune responses, reduces swelling, and prevents disease spread.
Area of Science:
- Immunology
- Dermatology
- Lymphatic Research
Background:
- The lymphatic system plays a vital role in skin immunity and health.
- Lymphatic dysfunction is implicated in various inflammatory skin conditions.
- Understanding lymphatic mechanisms is key to managing skin diseases.
Purpose of the Study:
- To review the relationship between lymphatic function and skin health.
- To explore the impact of lymphatic dysfunction on inflammatory skin disorders.
- To synthesize current research on lymphatics in skin cancer, autoimmune, and infectious diseases.
Main Methods:
- Systematic literature search across Web of Science, Embase, and Ovid MEDLINE.
- Adherence to Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews (PRISMA-ScR) guidelines.
- Inclusion of peer-reviewed human/animal studies (2014-2024) on inflammatory skin disorders.
Main Results:
- Lymphatics are essential for skin health, mitigating inflammation, infection, and skin cancer.
- A functional lymphatic system, supported by cytokines, reduces inflammation and lymphedema.
- Restoring lymphatic function improves immune cell migration and reduces infectious disease spread.
Conclusions:
- The skin lymphatic system is integral to immune surveillance and homeostasis.
- Lymphatic dysfunction significantly contributes to inflammatory skin disease pathogenesis.
- Targeting lymphatic function offers therapeutic potential for various skin conditions.
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