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Creation and Transplantation of an Adipose-derived Stem Cell ASC Sheet in a Diabetic Wound-healing Model
Published on: August 4, 2017
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Plant-Derived B-CGT Hydrogel Accelerates Diabetic Wound Healing Through Multitarget Modulation of Inflammation,
Fei Ran1, Kailang Mu1, Lingli Zhou1
1College of Pharmacy, Guizhou University of Traditional Chinese Medicine, Guiyang 550025, China.
Gels (Basel, Switzerland)
|February 25, 2025
Summary
This study shows a plant-derived hydrogel (B-CGT) effectively promotes diabetic wound healing by reducing inflammation and improving blood vessel formation. It offers a promising new strategy for treating chronic wounds.
Area of Science:
- Biomedical Engineering
- Pharmacology
- Wound Healing Research
Background:
- Diabetic wound healing is complicated by poor blood vessel growth, persistent inflammation, and cell dysfunction.
- Previous research indicated potential for plant-derived glucosyloxybenzyl 2-isobutylmalates (B-CGT) hydrogel in wound repair.
Purpose of the Study:
- To investigate the therapeutic potential and underlying mechanisms of B-CGT hydrogel for diabetic wound healing.
- To validate the efficacy of B-CGT hydrogel in preclinical models.
Main Methods:
- Network pharmacology and molecular docking were used to predict B-CGT's molecular targets and pathways.
- In vivo studies in diabetic mice assessed wound closure, angiogenesis, collagen deposition, and immune cell modulation.
- VEGF expression and antioxidant activity in the wound microenvironment were analyzed.
Main Results:
- B-CGT hydrogel significantly accelerated wound closure in diabetic mice.
- It enhanced angiogenesis, promoted collagen deposition, and rebalanced immune cells (macrophage polarization).
- B-CGT hydrogel improved the wound microenvironment by increasing VEGF and antioxidant effects.
Conclusions:
- B-CGT hydrogel demonstrates multi-target synergistic effects for diabetic wound healing.
- It addresses key challenges like immune imbalance and impaired angiogenesis.
- Findings support B-CGT hydrogel as a potential therapeutic strategy for chronic wound management.
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