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Related Concept Videos

T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

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T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
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Immunodeficiency Diseases01:25

Immunodeficiency Diseases

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Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
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T Cell Types and Functions01:24

T Cell Types and Functions

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When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
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Murine Model of CD40-activation of B cells
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CD6 in Human Disease.

Mikel Gurrea-Rubio1, David A Fox1, Javier S Castresana2

  • 1Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.

Cells
|February 25, 2025
PubMed
Summary
This summary is machine-generated.

CD6, a cell surface protein, is crucial for immune cell function and linked to autoimmune diseases. Targeting CD6 shows promise for treating various conditions, including cancer.

Keywords:
CD166CD318CD44CD6autoimmunityimmunotherapy

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Area of Science:

  • Immunology
  • Cell Biology
  • Molecular Medicine

Background:

  • CD6 is a cell surface protein found on lymphocytes, mediating crucial immune cell interactions.
  • Its ligands include CD166 (ALCAM) and CD318 (CDCP1), with CD44 emerging as a potential new ligand.
  • CD6 plays significant roles in lymphocyte activation, proliferation, and adhesion.

Purpose of the Study:

  • To analyze the multifaceted roles of CD6 in the pathogenesis of over 15 diseases.
  • To review current data supporting CD6-targeted therapies in human clinical applications.

Main Methods:

  • Literature review and analysis of existing research on CD6 function and disease association.
  • Examination of data on CD6-ligand interactions and their functional consequences.
  • Assessment of clinical data for CD6-targeted therapeutic strategies.

Main Results:

  • CD6 is implicated in the pathogenesis of numerous autoimmune diseases, particularly through its regulation of CD4+ T-cell responses.
  • CD6 interactions are vital for immune cell adhesion and activation.
  • CD6 presents a viable target for novel cancer immunotherapies.

Conclusions:

  • CD6 is a key regulator of immune responses with significant implications in disease pathogenesis.
  • Targeting CD6 offers a promising therapeutic avenue for autoimmune diseases and cancer immunotherapy.