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Updated: Jun 19, 2026
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Maintaining Human Glioblastoma Cellular Diversity Ex vivo using Three-Dimensional Organoid Culture
Published on: August 25, 2022
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Advancing Glioblastoma Research with Innovative Brain Organoid-Based Models
Cátia D Correia1,2, Sofia M Calado1,3, Alexandra Matos1
1Algarve Biomedical Center Research Institute (ABC-RI), Universidade do Algarve, Campus de Gambelas, 8005-139 Faro, Portugal.
Cells
|February 25, 2025
Summary
Brain organoid models offer a more accurate way to study glioblastoma (GBM), a complex brain cancer. These advanced models improve preclinical research and the development of new GBM treatments.
Area of Science:
- Neuro-oncology
- Cancer Biology
- Stem Cell Research
Background:
- Glioblastoma (GBM) is an aggressive brain cancer with high heterogeneity and a complex tumor microenvironment.
- Current in vitro and in vivo models often fail to fully replicate GBM's complexity.
- There is a need for more clinically relevant models to advance GBM research.
Purpose of the Study:
- To review the development and application of brain organoid models for glioblastoma research.
- To highlight the potential of these models in understanding GBM biology.
- To explore novel therapeutic strategies using brain organoid models.
Main Methods:
- Utilizing brain organoids derived from human-origin cells.
- Incorporating advanced genetic techniques and stem cell-based bioengineering.
- Developing and validating GBM models based on brain organoids.
Main Results:
- Brain organoid models have been developed and confirmed to be clinically relevant.
- These models contribute to advancing preclinical glioblastoma research.
- Organoid models enhance the study of GBM biology and therapeutic development.
Conclusions:
- Brain organoid models represent a significant advancement in studying glioblastoma.
- These models hold promise for improving the understanding and treatment of GBM.
- Innovative organoid approaches are crucial for developing more effective GBM therapies.
