Related Experiment Video
Updated: May 26, 2025
10:09
Rapid Genetic Analysis of Epithelial-Mesenchymal Signaling During Hair Regeneration
Published on: February 28, 2013
13.7K
Folliculogenesis: A Cellular Crosstalk Mechanism.
Bianca Viviana Orozco-Galindo1, Blanca Sánchez-Ramírez2, Cynthia Lizeth González-Trevizo3
1Facultad de Zootecnia y Ecología, Universidad Autónoma de Chihuahua (UACH), Perif. Fco. R. Almada Km. 1, 31453 Chihuahua, Mexico.
Current Issues in Molecular Biology
|February 25, 2025
Summary
This review explores cellular crosstalk during oocyte development in cows and women. Understanding these communication pathways can enhance in vitro maturation for improved fertility in both species.
Area of Science:
- Reproductive Biology
- Developmental Biology
- Comparative Physiology
Background:
- In vitro embryo production is advancing rapidly in the cattle industry.
- Human and bovine reproductive systems share similarities, offering comparative study opportunities.
- Oocyte competence is crucial for successful fertilization and embryo development.
Purpose of the Study:
- To review cellular crosstalk mechanisms during folliculogenesis in mammals.
- To understand oocyte competence development for improved in vitro maturation (IVM) protocols.
- To explore the potential of bovine models for studying human ovarian physiology.
Main Methods:
- Literature review focusing on cellular communication during folliculogenesis.
- Analysis of pre-pubertal and post-pubertal follicular development stages.
- Examination of gonadotropin hormone roles in oocyte maturation.
Main Results:
- Detailed description of cellular crosstalk in primordial, primary, and secondary follicles.
- Explanation of how gonadotropins influence oocyte maturation post-puberty.
- Identification of key communication events essential for oocyte competence.
Conclusions:
- Understanding follicular cell crosstalk is vital for improving IVM outcomes.
- Enhanced IVM can lead to higher quality oocytes and successful pregnancies in cattle and humans.
- Bovine models provide a valuable platform for investigating human reproductive physiology.
Related Concept Videos
01:20Folliculogenesis
475
Folliculogenesis is the development of ovarian follicles, the specialized structures within the ovarian cortex where oogenesis, or egg development, occurs. This process is essential for female reproductive health and begins during fetal development when primordial follicles are formed. Each primordial follicle comprises a primary oocyte in the center, surrounded by a single layer of squamous pre-granulosa cells. These follicles remain dormant in late prophase I of meiosis until triggered by...
475
01:06Multipotency and Niche of Bulge Stem Cell
3.3K
A hair follicle or HF is a small part of the skin that produces the hair shaft. Paul Gerson Unna was the first to observe a bulge in the human hair follicle's outer root sheath (ORS). The bulge is present between the sebaceous gland and the arrector pili muscle and is the niche for hair follicle stem cells (HFSCs). The bulge is also a niche for melanocyte stem cells, and their loss results in graying of hair. The HFSCs express Sox9 and Lhx2, which help them maintain stemness and prevent...
3.3K
02:36Cells Coordinate Growth and Proliferation
4.4K
Cell size is a significant factor impacting cellular design, function, and fitness. There exists some internal coordination by which cells double their masses before division, thus, achieving homeostasis. Coordination between cell growth and proliferation depends on the checkpoints in between cell cycle phases. Loss of coordination or failure in the checkpoint mechanism can drive the cell to uncontrolled growth and loss of cellular function. Like dividing cells that coordinate cellular growth,...
4.4K
02:38Mitogens and the Cell Cycle
6.4K
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
6.4K
00:57Cellular Differentiation
2.5K
How does a complex organism such as a human develop from a single cell? It all starts from a single fertilized egg which gives rise to a vast array of cell types, such as nerve cells, muscle cells, and epithelial cells that characterize the adult? Throughout development and adulthood, cellular differentiation leads cells to assume their final morphology and physiology. Differentiation is the process by which unspecialized cells become specialized to carry out distinct functions.
A zygote is a...
A zygote is a...
2.5K
01:16TGF - β Signaling Pathway
7.2K
The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors...
7.2K