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Optimizing Adherence to Oral Anticancer Agents: Results from an Implementation Mapping Study.

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This summary is machine-generated.

This study developed strategies to improve oral anticancer agent (OAA) adherence programs. Standardized tools like electronic health record (EHR) templates and standard operating procedures (SOPs) were highly effective.

Keywords:
implementation mappingmedication adherenceoral anticancer agentsoral chemotherapy

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Area of Science:

  • Oncology
  • Implementation Science
  • Health Services Research

Background:

  • Real-world cancer care outcomes frequently differ from clinical trial results due to patient-specific factors, including nonadherence to oral anticancer agents (OAAs).
  • Existing oncology guidelines recommend patient support programs, but practical implementation guidance remains scarce.

Purpose of the Study:

  • To enhance the adoption, implementation, and sustainability of an OAA adherence program (OAP) using a mixed-methods approach.
  • To co-develop practical strategies for improving OAA adherence in clinical settings.

Main Methods:

  • A two-phase, mixed-methods study employing implementation mapping (IM) with a multidisciplinary expert panel.
  • Phase 1: Development of six core strategies. Phase 2: Assessment of strategy feasibility, acceptability, and appropriateness through surveys and interviews with oncology professionals.

Main Results:

  • Six key strategies were developed: memorandum of understanding (MOU), data-driven presentation, standard operating procedures (SOPs), motivational interviewing (MI) training, electronic health record (EHR) templates, and key performance indicators (KPIs).
  • EHR templates and SOPs were identified as the most feasible and acceptable strategies.
  • Leadership support, phased implementation, and clear documentation were crucial for success, while resource limitations and staff workload presented challenges.

Conclusions:

  • Implementation mapping effectively co-developed strategies to establish OAA adherence programs.
  • Standardized clinical tools, specifically EHR templates and SOPs, are highly valued for improving OAA adherence.
  • Future research should evaluate these strategies in a hybrid trial to enhance real-world oncology patient outcomes.