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Updated: Aug 10, 2026
Depletion and Reconstitution of Macrophages in Mice
Published on: August 1, 2012
Defective macrophage function in wound repair of P/J mice
Abstract:
The strength of healing full-thickness incised dermal wounds in P/J mice was less than that of CD-1 mice although the strength of intact skin was similar for each strain. Five days after surgery, P/J mice had wounds with tensile strengths of 65 +/- 18g while CD-1 mice had wounds with strengths of 85 +/- 15g. The wound breaking strength of P/J mice was restored to normal values (86 +/- 18g) by administering glucan. The consequence of defective monocytes in wound repair is discussed in reference to P/J mice.
Insights
P/J mice exhibit weaker wound healing than CD-1 mice, but glucan administration normalizes healing strength. This suggests a role for monocytes in dermal wound repair.
Area of Science:
- Immunology
- Dermatology
- Wound Healing Research
Background:
- Intact skin strength is comparable between P/J and CD-1 mice strains.
- P/J mice demonstrate impaired healing of full-thickness dermal wounds compared to CD-1 mice.
Purpose of the Study:
- To investigate the difference in dermal wound healing strength between P/J and CD-1 mice.
- To explore the potential of glucan administration in restoring wound healing capacity in P/J mice.
- To discuss the implications of monocyte function in the context of P/J mice wound repair.
Main Methods:
- Comparative analysis of tensile strength in dermal wounds of P/J and CD-1 mice at five days post-surgery.
- Administration of glucan to P/J mice to assess its effect on wound breaking strength.
Main Results:
- P/J mice wounds had a tensile strength of 65 +/- 18g, while CD-1 mice wounds measured 85 +/- 15g.
- Glucan administration normalized the wound breaking strength in P/J mice to 86 +/- 18g.
Conclusions:
- Defective monocyte function in P/J mice may contribute to their reduced wound healing capacity.
- Glucan shows potential as a therapeutic agent to enhance dermal wound repair.
