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Antifungal Policy and Practice Across Five Countries: A Qualitative Review
David W Denning1, John R Perfect2, Neda Milevska-Kostova3,4
1Manchester Fungal Infection Group, The University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9PL, UK.
Journal of Fungi (Basel, Switzerland)
|February 25, 2025
Summary
Invasive fungal infections (IFIs) are rising globally. Policy assessments reveal significant gaps in IFI diagnostics, awareness, and integration into antimicrobial resistance strategies, hindering effective patient care and stewardship.
Area of Science:
- Infectious Diseases
- Public Health Policy
- Antimicrobial Stewardship
Background:
- Invasive fungal infections (IFIs) pose a growing global health burden.
- Effective national and regional policies are crucial for managing the evolving landscape of IFIs.
Purpose of the Study:
- To assess antifungal policies across five diverse countries (Netherlands, Italy, South Korea, China, India).
- To identify gaps in IFI management policies, including diagnostics, treatment, and awareness.
Main Methods:
- Comparative policy analysis of antifungal management strategies.
- Evaluation of policy elements: recognition, awareness, prevention, diagnosis, treatment access, and innovation.
- Selection of countries representing varied economic and health systems.
Main Results:
- All assessed countries have some IFI management policies, but substantial gaps exist.
- Key gaps include low prioritization of IFI diagnostics and exclusion of fungal pathogens from antimicrobial resistance policies.
- Limited awareness and healthcare professional training on IFI management were identified.
Conclusions:
- Identified policy gaps require attention from healthcare professionals and policymakers.
- Addressing these gaps is essential for reducing the IFI burden on patients and health systems.
- Improved policies support responsible antifungal stewardship and better IFI patient outcomes.

