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Indications, Management, and Short- and Medium-Term Outcomes of Patients with Chronic Coronary Occlusion Treated with

Lucia Barbieri1, Gabriele Tumminello1, Lorenzo Mafrici2

  • 1Department of Cardio-Thoracic-Vascular Diseases, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy.

Journal of Cardiovascular Development and Disease
|February 25, 2025
PubMed

Insights

Percutaneous coronary intervention (PCI) for chronic total occlusion (CTO) is a challenging procedure. This study shows PCI for CTO has a high success rate and low complication incidence in real-world practice.

Area of Science:

  • Cardiology
  • Interventional Cardiology

Background:

  • Chronic total occlusion (CTO) is a complete coronary artery blockage for ≥3 months.
  • CTO diagnosis is challenging, and it can be asymptomatic.
  • Indications for CTO recanalization lack randomized controlled trial support.

Purpose of the Study:

  • To assess indications, management, and procedural outcomes of percutaneous revascularization (PCI) for CTO.
  • To ensure a uniform patient population regarding technologies and methods.
  • To evaluate the safety and efficacy of CTO PCI in a real-world setting.

Main Methods:

  • Retrospective analysis of 41 consecutive patients undergoing PCI for CTO.
  • Data collected from January 2021 to 2024.
  • Outcomes included procedural success, mortality, major adverse cardiovascular events, and residual symptoms, with a median follow-up of 449 days.

Main Results:

  • High success rate for PCI in CTO recanalization.
  • Low incidence of major complications observed.
  • Favorable outcomes regarding mortality and major adverse cardiovascular events.

Conclusions:

  • Real-world data confirm PCI for CTO is a high-success, low-complication procedure.
  • Further research may be warranted to solidify indications based on robust evidence.
  • CTO PCI is a viable option for selected patients.

Keywords:
chronic total occlusioncoronary interventionpatient outcome

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