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Updated: May 26, 2025

MicroRNA Expression Profiles of Human iPS Cells, Retinal Pigment Epithelium Derived From iPS, and Fetal Retinal Pigment Epithelium
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Psoriasis Treatments: Emerging Roles and Future Prospects of MicroRNAs

Li Tian Keane Teo1, Nerissa Juantuah-Kusi2,3, Gowtham Subramanian3,4

  • 1Department of Life Sciences, Imperial College London, Sir Ernst Chain Building, South Kensington, London SW7 2AZ, UK.

Non-Coding RNA
|February 25, 2025
PubMed

Insights

Psoriasis is a chronic skin disease with no cure. MicroRNAs (miRNAs) are key regulators in its development and offer promising therapeutic potential for future treatments.

Area of Science:

  • Dermatology and Molecular Biology
  • Investigating the molecular mechanisms of skin diseases

Background:

  • Psoriasis is a chronic, inflammatory skin condition with complex pathogenesis.
  • Genetic, immunological, and environmental factors contribute to psoriasis development.
  • MicroRNAs (miRNAs) are increasingly recognized for their role in hyperproliferative skin disorders.

Purpose of the Study:

  • To review the emerging significance of miRNAs in psoriasis pathogenesis.
  • To examine the potential of miRNAs as therapeutic targets for psoriasis.

Main Methods:

  • This study is a narrative review of current research on miRNAs and psoriasis.
  • Literature search on microRNA regulation in hyperproliferative skin diseases.
  • Analysis of current psoriasis treatments and future therapeutic strategies.

Main Results:

  • MicroRNAs play a pivotal role in regulating key processes in psoriasis.
  • Dysregulation of specific miRNAs is implicated in psoriasis pathogenesis.
  • miRNAs represent a promising area for novel therapeutic interventions.

Conclusions:

  • MicroRNAs are significant regulators in the complex pathogenesis of psoriasis.
  • Targeting miRNAs offers a potential avenue for next-generation psoriasis therapies.
  • Further research into miRNA-based treatments could revolutionize psoriasis management.
Keywords:
inflammatory skin diseasesmicroRNAspathogenesispsoriasistherapeutics

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