Photoinduced synthesis of functionalized spiro[2.3]hexane via an additive-free approach
Dan Qi1,2, Jinrui Bai2, Yue Yao2
1College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China.
Abstract:
A general green protocol for the synthesis of spiro[2.3]hexane avoiding the use of harmful and toxic reagents is described. Spirocyclic scaffolds can be constructed by using alkenes of low reactivity under visible-light irradiation only. Several synthetic advantages of this method are exhibited, including mild conditions, good functional-group tolerance, operational simplicity, and scalability. Mechanistic studies indicate that C-C bond formation occurs almost simultaneously with a light-sustained initiation process.
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