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Updated: May 26, 2025

High-throughput Identification of Bacteria Repellent Polymers for Medical Devices
Published on: November 5, 2016
Inherent antibacterial properties of mannose-containing polynorbornene glycomaterials
Brady A Hall1,2, Ophelia J Wadsworth1, Logan M Breiner1,3
1Department of Chemistry, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA. alowell@vt.edu.
Abstract:
Monosaccharides are typically employed as targeting ligands in antimicrobial polymers, yet we discovered that certain glycopolymers prepared by ring-opening metathesis polymerization display inherent antibacterial activity, despite lacking conventional antimicrobial groups. Mannose-functionalized polymers proved potent against Escherichia coli, which could be rescued by adding excess mannose to the growth medium.
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