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Related Concept Videos

Electroconvulsive Therapy01:30

Electroconvulsive Therapy

22
Electroconvulsive therapy (ECT), or shock therapy, remains a critical biomedical intervention for severe, treatment-resistant depression. While its origins can be traced back to Hippocrates' observations that malaria-induced convulsions alleviated mental illness, modern ECT has evolved significantly from its earlier, more primitive applications. First introduced in 1938 by Ugo Cerletti and his colleagues, ECT involves inducing controlled seizures using electrical currents. In its early...
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Pupillary Response as Assessment of Effective Seizure Induction by Electroconvulsive Therapy
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Multicenter Observational Study of Electroconvulsive Therapy in Japan.

Takeshi Sakayori1, Ken Wada2, Minoru Takebayashi3

  • 1From the Department of Neuropsychiatry, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan.

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|February 25, 2025
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Summary

This study surveyed modified electroconvulsive therapy (ECT) in Japan, finding mood disorders most common. Efficacy was similar across diagnoses but higher in elderly patients, with few severe adverse events.

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Area of Science:

  • Psychiatry
  • Neurology
  • Clinical Medicine

Background:

  • Modified electroconvulsive therapy (ECT) is a vital treatment for severe mental health conditions.
  • Understanding current ECT practices in Japan is crucial for optimizing patient care.
  • This study represents the first large-scale, multicenter survey of modified ECT in Japan.

Purpose of the Study:

  • To assess the current implementation status of modified electroconvulsive therapy (ECT) in Japan.
  • To analyze patient demographics, diagnoses, and treatment outcomes of acute-phase ECT.
  • To evaluate the efficacy, safety, and adverse events associated with ECT.

Main Methods:

  • A multicenter observational study involving 21 certified ECT facilities in Japan.
  • Analysis of annual reports from 2016, including patient diagnoses, gender, age, efficacy, and adverse events.
  • Investigation of acute-phase ECT patient data, totaling 524 individuals.

Main Results:

  • Mood disorders (F3) were the most common indication (65.6%), followed by schizophrenia spectrum disorders (F2) (29.8%).
  • The mean patient age was 60.4 years, with 57.9% aged 60 or older.
  • Efficacy rates did not differ significantly by diagnosis or gender, but were higher in elderly patients. Four severe adverse events were reported.

Conclusions:

  • Modified ECT is a significant treatment option in Japan, primarily for mood disorders and schizophrenia.
  • Efficacy is comparable across diagnoses but notably higher in older patients.
  • Accumulating multicenter data can enhance the effectiveness and safety of ECT practices.