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Endocrine Controls of Skin Aging.

Markus Böhm1, Agatha Stegemann1, Ralf Paus2,3,4,5

  • 1Department of Dermatology, University of Münster, Münster 48149, Germany.

Endocrine Reviews
|February 25, 2025
PubMed
Summary
This summary is machine-generated.

Skin aging involves intrinsic and extrinsic factors, influenced by hormones. Research highlights key hormones like IGF-1, GH, estrogens, and melatonin, offering potential for new anti-aging therapies.

Keywords:
endocrinologyhormonesphotoagingsenescence

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Area of Science:

  • Dermatology and endocrinology.
  • Focus on skin aging mechanisms and hormonal regulation.

Background:

  • Skin aging results from intrinsic (genetic) and extrinsic (exposome) factors.
  • Both aging types share biochemical changes like oxidative stress and DNA damage.
  • Skin and hair follicles act as endocrine organs, influenced by neuroendocrine axes.

Purpose of the Study:

  • To review pivotal hormones that control human skin aging.
  • To explore the roles of both classical and emerging endocrine players.
  • To identify potential targets for novel anti-skin aging therapeutics.

Main Methods:

  • Comprehensive literature review of hormonal influences on skin aging.
  • Analysis of molecular and biochemical processes.
  • Evaluation of current clinical applications and future research directions.

Main Results:

  • Key hormones reviewed include IGF-1, GH, estrogens, and melatonin.
  • Emerging roles of α-MSH, thyroid axis hormones, oxytocin, endocannabinoids, and PPAR modulators are discussed.
  • Topical retinoids and estrogens are currently the primary hormonal anti-aging treatments.

Conclusions:

  • Hormonal regulation is crucial in both intrinsic and extrinsic skin aging.
  • Further research into endocrine players and derivatives may yield novel senotherapeutics.
  • Targeting hormonal pathways presents a promising avenue for skin aging prevention and treatment.