Related Experiment Video
Updated: May 26, 2025
14:56
Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies
Published on: May 6, 2022
4.4K
Adherence to the Mediterranean Diet and Obesity-Linked Cancer Risk in EPIC
Inmaculada Aguilera-Buenosvinos1,2, Fernanda Morales Berstein3,4, Esther M González-Gil5
1Department of Preventive Medicine and Public Health, University of Navarra, Pamplona, Spain.
JAMA Network Open
|February 25, 2025
Summary
Higher adherence to the Mediterranean Diet (MedDiet) is linked to a reduced risk of obesity-related cancers (ORCs). This association appears independent of body mass index and waist-to-hip ratio, suggesting a direct protective effect of the MedDiet.
Area of Science:
- Nutrition Science
- Oncology
- Epidemiology
Background:
- The Mediterranean Diet (MedDiet) is associated with lower cancer incidence and reduced weight gain.
- Obesity is a significant risk factor for various cancers, and MedDiet adherence shows an inverse relationship with obesity.
Purpose of the Study:
- To investigate the association between MedDiet adherence and the risk of obesity-related cancers (ORCs).
- To explore the potential mediating role of adiposity in this association.
Main Methods:
- Prospective cohort study using data from the European Prospective Investigation Into Cancer and Nutrition (EPIC) study.
- MedDiet adherence scored on a 9-point scale; ORC incidence classified by International Agency for Research on Cancer criteria.
- Multivariable Cox proportional hazards regression and mediation analyses were employed.
Main Results:
- Over 450,000 participants followed for a median of 14.9 years.
- Higher MedDiet adherence (7-9 points) was associated with a modest, statistically significant reduction in ORC risk (HR, 0.94; 95% CI, 0.90-0.98) compared to low adherence (0-3 points).
- Mediation analyses did not support a role for waist-to-hip ratio or body mass index in the MedDiet-ORC risk relationship.
Conclusions:
- Increased adherence to the MedDiet is associated with a modest reduction in ORC risk.
- This protective association appears to be independent of adiposity measures.
- Further research is warranted to elucidate the precise mechanisms underlying the MedDiet's role in cancer prevention.
More Related Videos
Related Concept Videos
02:59Cancer Prevention
6.0K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.0K
01:24Obesity
361
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
361
03:03mTOR Signaling and Cancer Progression
3.7K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
3.7K
01:19Psychoneuroimmunology: Diabetes and Cancer
21
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
21
02:18Cancer
47.4K
Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
47.4K
01:29Cholesterol: Significance and Regulation
496
Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
Considering cholesterol and...
496