68 Ga-DOTATOC PET/CT of Glomus Tumor of the Small Bowel
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View abstract on PubMed
Summary
This summary is machine-generated.A rare glomus tumor mimicked a neuroendocrine tumor (NET) on imaging, despite negative biomarkers. Molecular imaging with Gallium-68 DOTATOC PET/CT showed high somatostatin receptor 2 (SSTR-2) expression, complicating the diagnosis.
Area Of Science
- Oncology
- Radiology
- Pathology
Background
- Neuroendocrine tumors (NETs) are a heterogeneous group of neoplasms.
- Glomus tumors are rare mesenchymal tumors that can occur in various locations.
- Distinguishing between NETs and other hypervascular lesions can be challenging.
Purpose Of The Study
- To report a case of a hypervascular small bowel lesion with an unusual presentation.
- To highlight the utility of molecular imaging in characterizing gastrointestinal tumors.
- To discuss the differential diagnosis of small bowel tumors.
Main Methods
- A 57-year-old woman underwent contrast-enhanced CT for suspected renal graft infection.
- Biochemical markers including serum chromogranin A and urinary 5-HIAA were assessed.
- Gallium-68 DOTATOC PET/CT was performed for molecular imaging.
- Histopathological examination with immunohistochemistry was conducted.
Main Results
- An incidental hypervascular small bowel lesion was identified.
- Biochemical markers for NETs were negative.
- Gallium-68 DOTATOC PET/CT demonstrated high somatostatin receptor 2 (SSTR-2) expression.
- Pathology revealed a glomus tumor with diffuse alpha-smooth muscle actin positivity.
Conclusions
- This case underscores the potential for molecular imaging to reveal overlapping targets between different tumor types.
- Glomus tumors can exhibit SSTR-2 expression, mimicking neuroendocrine tumors.
- Accurate diagnosis requires integration of imaging, biochemical, and histopathological findings.
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