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Complete genome sequence of three methicillin-resistant Staphylococcus aureus ST630 strains isolated from cattle in

Chahrazed Belhout1, Javier E Fernandez1, Vincent Perreten1

  • 1Division of Molecular Bacterial Epidemiology and Infectious Diseases, Vetsuisse Faculty, Institute of Veterinary Bacteriology, University of Bern, Bern, Switzerland.

Microbiology Resource Announcements
|February 25, 2025
PubMed

Insights

Emerging Methicillin-resistant Staphylococcus aureus (MRSA) ST630 in cattle shares genetic traits with human strains. This finding highlights potential zoonotic transmission risks of this important pathogen.

Area of Science:

  • Microbiology
  • Genomics
  • Veterinary Science

Background:

  • Methicillin-resistant Staphylococcus aureus (MRSA) sequence type 630 (ST630) is an emerging clone responsible for human infections.
  • Understanding the genetic makeup of MRSA strains in animal reservoirs is crucial for public health.

Purpose of the Study:

  • To characterize the complete genomes of MRSA ST630 isolates from cattle.
  • To investigate the genetic relatedness of bovine MRSA ST630 to human-associated strains.

Main Methods:

  • Whole-genome sequencing of three MRSA ST630 isolates from cattle.
  • Comparative genomic analysis.

Main Results:

  • The complete genomes of three bovine MRSA ST630 were sequenced, each approximately 2.8 Mbp.
  • These genomes harbor genes conferring antimicrobial resistance and virulence.
  • Genomic analysis revealed a close relationship between these bovine strains and previously identified human-associated MRSA ST630.

Conclusions:

  • Bovine MRSA ST630 possess genetic elements associated with virulence and antimicrobial resistance.
  • The genetic similarity suggests a potential link or shared ancestry between cattle and human MRSA ST630 strains.
  • This study underscores the importance of monitoring MRSA in livestock for potential zoonotic implications.
Keywords:
MRSA ST630animalscomplete genome

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