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Updated: May 25, 2025
Surgical Techniques for Catheter Placement and 5/6 Nephrectomy in Murine Models of Peritoneal Dialysis
Published on: July 19, 2018
Five-Year Time Profiles of Clearances of Different Uremic Solutes in Incident Peritoneal Dialysis Patients
Ji Ji1,2,3,4, Min Lu1,2,3,4, Shulan Guo1,2,3,4
1Department of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, China.
Introduction:
Different uremic solutes have varying degrees of clearances owing to different chemical properties and the pathological and physiological changes in the kidneys and peritoneum.
Methods:
The 5-year time profiles of renal, peritoneal, and total clearances of creatinine, urea nitrogen (UN), uric acid (UA), trimethylamine
Results:
Peritoneal clearances of creatinine, UN, UA, and phosphate increased over time, while the peritoneal clearance of IL-6 showed a downward trend. The peritoneal clearances of TMAO, β2-MG, IS, and PCS did not change significantly. Patients in early start group showed a lower level of variation and a higher average of renal clearances. IPD patients had a higher level of total clearances of uremic solutes than full-dose PD patients in the first 3 years after PD initiation.
Conclusion:
In a long-term follow-up period, the peritoneal clearance of water-soluble small solutes increased over time, but that of protein-bound toxins and middle molecules did not. Initiating PD when residual kidney function remains at a relatively high level and performing IPD may better improve the efficiency of PD and help preserve the renal clearances of uremic solutes.
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