Related Experiment Video
Updated: May 25, 2025

13:04
In Vivo and Ex Vivo Approaches to Study Ovarian Cancer Metastatic Colonization of Milky Spot Structures in Peritoneal Adipose
Published on: October 14, 2015
13.0K
Scottish ovarian cancer forum
Mary Cairns1, Nidal Ghaoui Dit Ebef2,
1Aberdeen Royal Infirmary, Aberdeen, UK mary.cairns@nhs.scot.
BMJ Open Quality
|February 25, 2025
Summary
A new multidisciplinary forum improved surgical decision-making for advanced ovarian cancer patients. This collaborative review standardized care and aimed to increase surgical rates in two cancer networks.
Area of Science:
- Oncology
- Surgical Oncology
- Cancer Care
Background:
- Advanced ovarian cancer (stages 3/4) requires complex treatment decisions.
- Multidisciplinary input is crucial for optimizing surgical outcomes.
- Standardization of care pathways can improve patient management.
Purpose of the Study:
- To establish a real-time, multidisciplinary review forum for advanced ovarian cancer.
- To standardize surgical decision-making for upfront or interval surgery.
- To increase surgical resection rates in eligible patients.
Main Methods:
- Weekly virtual meetings using TEAMS.
- Inclusion of all relevant disciplines: radiology, medical oncology, gynecological oncology, clinical nurse specialists, colorectal and hepato-pancreatico-biliary surgeons.
- Review of radiology and assessment of surgical resection feasibility.
Main Results:
- Successful implementation of a collaborative review process.
- Facilitation of standardized surgical decision-making.
- Potential for increased surgical rates (further data needed).
Conclusions:
- A real-time, multidisciplinary forum can effectively standardize surgical decision-making for advanced ovarian cancer.
- This collaborative approach enhances the review of complex cases.
- The initiative supports improved patient stratification and management.
Related Concept Videos
Ovaries
620
The ovaries are roughly the size of almonds and measure approximately 2 to 3 centimeters in length. These paired structures are situated within the pelvic region and are anchored by the mesovarium—a peritoneal extension that also connects them to the wider structure of the broad ligament. The support system extends to the suspensory ligament, housing blood and lymphatic vessels. In addition, the ovarian ligament tethers the ovaries to the uterus.
On the ovarian surface, a layer of...
On the ovarian surface, a layer of...
620
Treatment Resistant Cancers
3.2K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.2K
Cancer Prevention
6.0K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.0K
Cancer Therapies
7.5K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.5K
Cancer-Critical Genes II: Tumor Suppressor Genes
7.3K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
7.3K
mTOR Signaling and Cancer Progression
3.7K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
3.7K

