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Sharpening the Blade of Precision Theranostics.
Geoffrey M Currie1, Eric M Rohren1
1Charles Sturt University, New South Wales, Australia; Baylor College of Medicine, TX, USA.
Seminars in Nuclear Medicine
|February 25, 2025
Summary
Precision theranostics in nuclear medicine offers personalized healthcare. Enhancing current practices with predictive dosimetry and improved theranostic pairs can further advance precision medicine in cancer care.
Area of Science:
- Nuclear Medicine
- Oncology
- Radiochemistry
Background:
- Theranostics leverages long-standing nuclear medicine principles for personalized healthcare.
- Recent advancements have spurred enthusiasm and standardized procedures in theranostics.
- Current practices present opportunities for enhancing precision in theranostic applications.
Purpose of the Study:
- To explore key considerations for advancing the field of theranostics.
- To identify limitations in current theranostic approaches and highlight areas for improvement.
- To discuss the evolution of theranostics towards true precision medicine.
Main Methods:
- Review of current theranostic principles and practices.
- Analysis of standardized dosing regimes versus predictive dosimetry.
- Evaluation of the biological and chemical matching of theranostic pairs.
Main Results:
- Standardized activity-based dosing may limit precision compared to absorbed dose-based methods.
- Predictive dosimetry offers potential enhancements for patient outcomes.
- A need exists for better matching of biological and chemical properties in theranostic pairs.
Conclusions:
- Current best practices in theranostics may not fully align with future precision medicine goals.
- Advances in instrumentation, radiochemistry, and clinical domains require parallel progress in all areas of theranostics.
- Developing more authentic theranostic pairs is crucial for maximizing clinical benefits.
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