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Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms
Published on: May 29, 2020
Rheumatological diseases in patients with autoimmune hepatitis in a fourth level hospital in Bogotá between 2013 and
Juan Sebastián Almánzar Cortés1, Cathalina Vergara Cabra1, María Paula Uchima-Vera2
1Departamento de Medicina Interna, Fundación Santa Fe de Bogotá, Bogotá, Colombia.
Introduction:
Autoimmune hepatitis (AIH) is a chronic inflammatory liver disease with low prevalence worldwide. The coexistence of this entity with rheumatic diseases has been evaluated in multiple studies and is highly variable. The objective of this study is to identify the frequency of coexistence of rheumatic diseases and autoimmune hepatitis in adults who have been treated for 10 years in a fourth-level hospital in Bogota, Colombia.
Materials And Methods:
Analytical, observational, cross-sectional study in a single center that included patients over 18 years of age of both sexes with a diagnosis of AIH by simplified score ≥7 points, with a medical history registered at the Fundacion Santa Fe de Bogota in Bogota, Colombia between January 2013 and December 2023.
Results:
A total of 66 patients met inclusion criteria. 36.4% of patients had a concomitant autoimmune disease, with Sjögren's syndrome, systemic lupus erythematosus and autoimmune thyroid disease being the most prevalent.
Conclusion:
The frequency of coexistence of autoimmune hepatitis with rheumatic diseases in adult patients is 36.4% for the cohort studied, which is within the range of what has already been reported globally, where a prevalence of 14 to 44% has been described.
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