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Environmental Drivers of Malignant Clonal Selection in Precancerous Lesion Evolution
Yancheng Lai1,2, Shaosen Zhang1,2
1Department of Etiology and Carcinogenesis, National Cancer Center/National Clinical Research Center/Cancer Hospital, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China.
None:
Somatic mutations accumulation and subsequent malignant clonal selection are the processes that lead to cancer. The intricacy includes exposure to carcinogens as well as the ways in which these exposures interact with genetic, polygenic, or epigenetic predispositions. It is worthwhile to investigate how environmental factors influence the initial transformation of healthy cells into malignant ones, or their effects on promoting growth, invasion, immune evasion, inflammation and drug resistance of onset cancerous cells.
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