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Measurement of BK-polyomavirus Non-Coding Control Region Driven Transcriptional Activity Via Flow Cytometry
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Novel Human Polyomaviruses Discovered From 2007 to the Present: An Update of Current Knowledge

Mohammad Mehdi Fazeli1, Sara Heydari Sirat1, Somayeh Shatizadeh Malekshahi1

  • 1Department of Virology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.

Reviews in Medical Virology
|February 25, 2025
PubMed

Insights

Recent discoveries reveal novel human polyomaviruses (HPyVs) with diverse characteristics. While typically harmless, some HPyVs cause severe disease in immunocompromised individuals, necessitating further research.

Area of Science:

  • Virology
  • Infectious Diseases
  • Molecular Biology

Background:

  • Human polyomaviruses (HPyVs) are common, often causing asymptomatic infections.
  • Immunocompromised individuals are susceptible to severe HPyV-associated diseases.
  • Significant advancements in HPyV research have occurred since 2007.

Purpose of the Study:

  • To review the biology, tropism, epidemiology, and diseases associated with novel HPyVs discovered from 2007 onwards.
  • To highlight the knowledge gaps regarding newly identified HPyV strains.
  • To emphasize the clinical relevance of HPyV research.

Main Methods:

  • Literature review of studies published from 2007 to the present.
  • Compilation of data on HPyV biology, tissue tropism, and epidemiology.
  • Analysis of disease associations for newly discovered HPyVs.

Main Results:

  • Over a dozen novel HPyVs have been identified since 2007.
  • These novel HPyVs exhibit diverse biological and epidemiological profiles.
  • Some HPyVs have established disease links, while others remain poorly understood.

Conclusions:

  • The discovery of novel HPyVs has expanded our understanding of viral diversity and evolution.
  • Further research is crucial to elucidate the clinical significance and pathogenic potential of enigmatic HPyVs.
  • Continued investigation is essential for managing HPyV infections, particularly in vulnerable populations.
Keywords:
human diseasehuman polyomavirusesimmunocompromised patientsskin diseaseviral infection

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