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Association of blood lipids with mortality in COVID-19 patients

Cansu Memiç-İnan1, Mustafa Çapraz2, Aylin Çapraz3

  • 1Faculty of Health Sciences, Department of Nutrition and Dietetics, Hitit University, Çorum, Turkey.

Lipids
|February 25, 2025
PubMed

Insights

Lower levels of high-density lipoprotein (HDL) and low-density lipoprotein (LDL) cholesterol were associated with increased mortality risk in hospitalized coronavirus disease 2019 (COVID-19) patients. Monitoring lipid profiles is crucial for managing COVID-19 outcomes.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Biochemistry

Background:

  • Lipid metabolism plays a role in inflammatory responses and disease severity.
  • Understanding the relationship between lipid profiles and COVID-19 mortality is critical for patient management.

Purpose of the Study:

  • To investigate the association between lipid levels and mortality in hospitalized coronavirus disease 2019 (COVID-19) patients.
  • To determine if specific lipid parameters predict mortality risk in COVID-19.

Main Methods:

  • Retrospective cohort study of 501 COVID-19 patients admitted between April 2020 and 2021.
  • Analysis of biochemical tests including high-density lipoprotein (HDL), low-density lipoprotein (LDL), triglycerides, total cholesterol, and c-reactive protein (CRP).
  • Comparison of lipid levels and other parameters between survivors and non-survivors.

Main Results:

  • Survivors had higher levels of total cholesterol, HDL, LDL, and lymphocytes compared to non-survivors.
  • Lower levels of LDL and HDL cholesterol were significantly associated with an increased risk of mortality in COVID-19 patients.
  • Non-survivors exhibited lower HDL and LDL cholesterol levels and higher CRP, neutrophil, and white blood cell counts.

Conclusions:

  • Alterations in lipoprotein metabolism are linked to mortality in COVID-19 patients.
  • Low HDL and LDL cholesterol levels are predictive of increased mortality risk.
  • Routine evaluation and monitoring of blood lipid profiles are recommended for hospitalized COVID-19 patients.

Keywords:
COVID‐19blood lipidsmortality

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