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Updated: May 11, 2026

Detection of a CDH1 Rare Transcript Variant in Fresh-frozen Gastric Cancer Tissues by Chip-based Digital PCR

Detection of a CDH1 Rare Transcript Variant in Fresh-frozen Gastric Cancer Tissues by Chip-based Digital PCR

Published on: February 5, 2018

A spatial transcriptomic signature of 26 genes resolved at single-cell resolution characterizes high-risk gastric

Robert J Huang¹, Ignacio A Wichmann^2,3,4, Andrew Su⁵

¹Division of Gastroenterology, Department of Medicine, Stanford School of Medicine, Stanford, CA, 94305, USA.

NPJ Precision Oncology

|February 25, 2025

Summary

This summary is machine-generated.

Gastric intestinal metaplasia progression varies. A 26-gene signature in aberrant intestinal cells indicates immature lineage roles in high-risk precursor carcinogenesis, aiding gastric cancer prevention strategies.

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Last Updated: May 11, 2026

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Published on: February 5, 2018

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Published on: July 6, 2022

Area of Science:

Gastroenterology and Oncology
Molecular Biology
Cancer Research

Background:

Gastric cancer precursor progression rates vary significantly.
High-risk gastric intestinal metaplasia (GIM) carries a substantially increased risk for neoplasia.
Biological distinctions between high- and low-risk GIM remain poorly understood.

Purpose of the Study:

To characterize the microenvironment of advanced gastric cancer precursors compared to low-risk lesions.
To identify molecular differences associated with high-risk GIM progression.
To explore the role of cellular lineages in gastric carcinogenesis.

Main Methods:

Utilized multiple clinical cohorts for analysis.
Employed bulk, spatial, and single-cell gene expression assays.
Developed and validated a 26-gene panel associated with advanced lesions.

Main Results:

Identified a 26-gene panel distinguishing advanced GIM from low-risk lesions.
This signature localizes to metaplastic glands and aberrant intestinal cells.
Aberrant expression observed in mature and immature intestinal cells not typically found in the healthy stomach.

Conclusions:

A specific gene expression signature highlights the role of immature intestinal lineages in high-risk GIM.
These immature lineages may drive carcinogenesis within the metaplastic microenvironment.
Findings support the development of novel biomarkers and gastric cancer prevention strategies.