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Dialysis01:27

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Renal failure occurs when the kidneys lose their ability to filter waste products from the blood effectively. It can be classified into two types: acute renal failure (ARF) and chronic renal failure (CRF).
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Acute diarrhea, a common gastrointestinal disturbance, is characterized by the rapid evacuation of fluid stools, leading to an excessive weight in fluid. This condition typically arises from disorders affecting intestinal water and electrolyte transport. It can be triggered by an increased osmotic load within the intestine, excessive secretion of electrolytes and water, mucosal exudation of protein and fluid, or altered intestinal motility. The primary risks of acute diarrhea are dehydration...
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Decrease in Escherichia-Shigella in the gut microbiota of ESKD patients undergoing maintenance hemodialysis.

Yunlong Qin1, Jin Zhao2, Lihui Wang1

  • 1Department of Nephrology, Bethune International Peace Hospital, No.398 Zhongshan West Road, Shijiazhuang, Hebei, 050051, China.

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|February 25, 2025
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Summary

Gut microbiota alterations, particularly a decrease in Escherichia-Shigella, characterize patients with end-stage kidney disease (ESKD) undergoing hemodialysis. This finding suggests potential therapeutic targets for managing ESKD.

Keywords:
Chronic kidney diseaseEnd-stage kidney diseaseEscherichia-ShigellaGut microbiotaMaintenance hemodialysis

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Area of Science:

  • Microbiology
  • Nephrology
  • Gastroenterology

Background:

  • Gut dysbiosis is implicated in chronic kidney disease (CKD) and end-stage kidney disease (ESKD) pathogenesis.
  • However, consistent conclusions on gut microbiota differences in hemodialysis patients are lacking.

Purpose of the Study:

  • To investigate and characterize the gut microbial community structure in patients undergoing maintenance hemodialysis (MHD).
  • To identify specific microbial alterations associated with ESKD and MHD treatment.

Main Methods:

  • Analysis of gut microbiota structure in 20 MHD patients and 20 healthy controls (HC) using 16S rRNA gene sequencing.
  • Amplicon Sequence Variant (ASV) analysis to identify differences in microbial composition between groups.

Main Results:

  • Significant differences in gut microbial communities were observed between MHD patients and HC.
  • Key genera such as Escherichia-Shigella showed decreased abundance in MHD patients.
  • Increased abundance of genera including Phascolarctobacterium and Erysipelatoclostridium was noted in MHD patients.

Conclusions:

  • A decreased abundance of Escherichia-Shigella is a potential signature alteration in the gut microbiota of ESKD patients on MHD.
  • Escherichia-Shigella warrants further investigation as a key bacterial group in hemodialysis.
  • Gut microbiota dysbiosis presents a promising therapeutic target and diagnostic biomarker for MHD management.