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Sesquiterpene Lactones as Promising Phytochemicals to Cease Metastatic Propagation of Cancer

Fatemeh Mehdikhani1, Homa Hajimehdipoor2, Mojgan Tansaz3

  • 1Department of Clinical Biochemistry, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran 1985717411, Iran.

Biomolecules
|February 26, 2025
PubMed

Insights

Sesquiterpene lactones, plant-derived compounds, show potential in inhibiting cancer metastasis. This review details how these phytochemicals target key molecular pathways to suppress cancer cell invasion and migration.

Area of Science:

  • Oncology
  • Pharmacology
  • Phytochemistry

Background:

  • Cancer metastasis is a critical challenge, responsible for over 90% of cancer deaths.
  • Metastasis involves cancer cells spreading from the primary site to distant organs via a multi-step process.
  • Cellular signaling pathways regulate metastatic propagation in various cancers.

Purpose of the Study:

  • To review the process of cancer metastasis.
  • To explore the role of sesquiterpene lactones in inhibiting cancer metastasis.
  • To detail the molecular mechanisms underlying the anti-metastatic effects of sesquiterpene lactones.

Main Methods:

  • Literature review of cancer metastasis.
  • Analysis of studies on plant-derived phytochemicals, specifically sesquiterpene lactones.
  • Examination of molecular targets and signaling pathways affected by sesquiterpene lactones.

Main Results:

  • Sesquiterpene lactones, a class of phytochemicals, exhibit anti-metastatic properties.
  • These compounds act on multiple cell-signaling pathways to suppress cancer progression.
  • Sesquiterpene lactones effectively inhibit cancer cell invasion, migration, and metastasis.

Conclusions:

  • Sesquiterpene lactones represent a promising therapeutic strategy against cancer metastasis.
  • Targeting molecular factors involved in metastasis with phytochemicals offers a novel approach to cancer treatment.
  • Further research into sesquiterpene lactones could lead to new anti-cancer therapies.
Keywords:
angiogenesiscancer metastasisphytochemicalssesquiterpene lactonessignaling pathways

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