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Orthophenylphenol mutagenicity in a human cell strain.

H Suzuki, N Suzuki, M Sasaki

    Mutation Research
    |April 1, 1985
    PubMed
    Summary

    Orthophenylphenol (OPP), a common fungicide, was found to be mutagenic in human cells. OPP induced gene mutations more effectively than ultraviolet (UV) radiation, indicating its potential genotoxicity.

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    Area of Science:

    • Toxicology
    • Genetics
    • Cell Biology

    Background:

    • Orthophenylphenol (OPP) is a widely utilized fungicide with broad applications.
    • Assessing the genotoxic potential of widely used chemicals is crucial for public health and environmental safety.

    Purpose of the Study:

    • To investigate the mutagenic activity of Orthophenylphenol (OPP) in a human cell line.
    • To compare the mutagenicity of OPP with ultraviolet (UV) radiation.

    Main Methods:

    • Human RSa cells, sensitive to ultraviolet (UV) radiation, were exposed to varying doses of OPP.
    • The induction of ouabain-resistant (OuaR) mutants was quantified to assess mutagenicity.
    • Mutation frequencies were analyzed in a dose-dependent manner.

    Main Results:

    • Orthophenylphenol (OPP) treatment resulted in a dose-related increase in ouabain-resistant (OuaR) mutants.
    • OPP demonstrated higher mutagenic potency than UV radiation at equivalent survival rates.
    • These findings indicate a significant mutagenic effect of OPP.

    Conclusions:

    • Orthophenylphenol (OPP) exhibits mutagenic activity in human cells.
    • Further research into the genotoxicity of OPP is warranted.
    • The study highlights the need for careful evaluation of fungicide safety.

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