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Related Concept Videos

Types of RNA01:23

Types of RNA

Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
Ribosomal RNA Synthesis02:53

Ribosomal RNA Synthesis

Ribosome synthesis is a highly complex and coordinated process involving more than 200 assembly factors. The synthesis and processing of ribosomal components occurs not only in the nucleolus but also in the nucleoplasm and the cytoplasm of eukaryotic cells.
Ribosome biogenesis begins with the synthesis of 5S and 45S pre-rRNAs by distinct RNA polymerases. The primary transcripts are extensively processed and modified before they are bound and folded by ribosomal proteins and assembly factors,...
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...
Experimental RNAi02:15

Experimental RNAi

RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...
Types of RNA01:20

Types of RNA

Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...

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Related Experiment Video

Updated: Jun 27, 2026

Enhanced Northern Blot Detection of Small RNA Species in Drosophila Melanogaster
09:39

Enhanced Northern Blot Detection of Small RNA Species in Drosophila Melanogaster

Published on: August 21, 2014

Non-Coding RNAs in Cancer: Structure, Function, and Clinical Application.

Éva Márton1, Alexandra Varga1, Dóra Domoszlai1

  • 1Department of Human Genetics, Faculty of Medicine, University of Debrecen, H-4032 Debrecen, Hungary.

Cancers
|February 26, 2025
PubMed
Summary
This summary is machine-generated.

Non-coding RNAs (ncRNAs) are revolutionizing oncology, offering potential for early cancer diagnosis and novel therapies. This review explores diverse ncRNA types and their clinical applications.

Keywords:
RNARNA detectioncancercancer diagnosticscancer therapycircRNAlncRNAmiRNAsnRNAsnoRNA

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Enhanced Northern Blot Detection of Small RNA Species in Drosophila Melanogaster
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Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
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Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells

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Area of Science:

  • Oncology
  • Molecular Biology
  • Genomics

Background:

  • Personalized cancer medicine is evolving with genomic and transcriptomic profiling.
  • Non-coding RNAs (ncRNAs) significantly influence cancer progression and metastasis.
  • Cell-free ncRNAs may mediate intercellular communication in cancer.

Purpose of the Study:

  • To review diverse non-coding RNA species, including miRNAs, siRNAs, lncRNAs, and circRNAs.
  • To explore the structure, origin, function, and clinical potential of various ncRNAs.
  • To provide clarity on the vast literature regarding ncRNAs in oncology.

Main Methods:

  • Literature review focusing on diverse ncRNA species.
  • Discussion of molecular detection and functional study methods (in vitro and in vivo).
  • Analysis of ncRNAs' roles in regulating gene expression at transcriptional and post-transcriptional levels.

Main Results:

  • ncRNAs play critical roles in regulating oncogenic and tumor suppressor proteins.
  • ncRNAs are promising candidates for cancer biomarkers and therapeutic agents.
  • Various ncRNA types (miRNAs, siRNAs, lncRNAs, circRNAs, etc.) have distinct functions and clinical relevance.

Conclusions:

  • ncRNAs represent a paradigm shift in theoretical and clinical oncology.
  • Overcoming challenges in ncRNA research will usher in a new era of cancer diagnosis and therapy.
  • The future of oncology will be reshaped by personalized approaches leveraging ncRNAs.