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Related Experiment Video

Updated: May 5, 2026

Evaluation of Biomarkers in Glioma by Immunohistochemistry on Paraffin-Embedded 3D Glioma Neurosphere Cultures
06:32

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Epitranscriptomics in the Glioma Context: A Brief Overview.

Pablo Santamarina-Ojeda1,2,3,4,5, Agustín F Fernández1,2,3,4,5, Mario F Fraga1,2,3,4,5

  • 1Foundation for Biomedical Research and Innovation in Asturias (FINBA), 33011 Oviedo, Spain.

Cancers
|February 26, 2025
PubMed
Summary

Epitranscriptomics, the study of RNA modifications, adds a new layer to epigenetics. This review explores RNA modifications in gliomas and their therapeutic potential.

Keywords:
RNAepitranscriptomicsgliomamRNAmethylation

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Area of Science:

  • Epitranscriptomics and its role in cellular regulation.
  • RNA modifications as a new layer of epigenetic control.

Background:

  • Epitranscriptomics complements DNA and histone epigenetics.
  • Key RNA modifications include N6-methyladenosine, pseudouridine, and inosine.
  • These modifications impact transcription, splicing, RNA stability, and translation.

Purpose of the Study:

  • To review main RNA modifications.
  • To explore the interplay between modified and unmodified RNA.
  • To investigate the contribution of RNA modifications to glioma phenotypes and therapeutic strategies.

Main Methods:

  • Literature review of epitranscriptomics.
  • Analysis of RNA modification roles in cellular processes.
  • Examination of glioma-specific epitranscriptomic signatures.

Main Results:

  • RNA modifications are widespread and affect fundamental cellular processes.
  • Specific epitranscriptomic signatures are implicated in glioma development.
  • Understanding these modifications offers potential therapeutic targets.

Conclusions:

  • Epitranscriptomics is a critical area in cellular regulation.
  • RNA modifications play a significant role in glioma tumorigenesis.
  • Targeting epitranscriptomic mechanisms presents a promising therapeutic avenue for gliomas.