NON-SMALL-CELL LUNG CANCER: Real-World Population-Based Cohorts' Study
Alessandra Buja1, Massimo Rugge2, Alberto Bortolami3
1Department of Cardiologic, Vascular and Thoracic Sciences, and Public Health, University of Padova, Via Loredan, 18, 35100 Padova, Italy.
Cancers
|February 26, 2025
Summary
The 2019 cohort of non-small cell lung cancer (NSCLC) patients showed lower mortality risk and improved cancer-specific survival compared to 2017. However, the 2019 cohort incurred higher treatment costs, primarily due to drug administration and services.
Area of Science:
- Oncology
- Health Economics
- Epidemiology
Background:
- Retrospective analysis of non-small cell lung cancer (NSCLC) patients.
- Utilizes data from the Veneto Region cancer registry for 2017 and 2019 cohorts.
- Focuses on patient outcomes and treatment costs.
Purpose of the Study:
- To evaluate differences in clinical outcomes and treatment costs between NSCLC patients diagnosed in 2017 and 2019.
- To assess the impact of changes in management on survival and healthcare expenditure.
- To inform real-world oncology practice regarding cost-effectiveness and patient care.
Main Methods:
- Comparison of two incident NSCLC cohorts (2017: 493 patients, 2019: 557 patients).
- Three-year follow-up post-diagnosis for outcome assessment.
- Cox regression for survival analysis; linear regression for treatment cost analysis.
Main Results:
- The 2019 cohort demonstrated significantly lower overall mortality risk (HR 0.84; p=0.024).
- Stage III NSCLC patients in the 2019 cohort showed significantly higher cancer-specific survival (HR 0.61; p=0.015).
- The 2019 cohort incurred higher overall treatment costs (coefficient 0.16; p=0.025), driven by drug administration, outpatient services, and medical devices, but lower costs for hospice and hospitalizations.
Conclusions:
- Significant differences observed in clinical outcomes and patient-related costs between 2017 and 2019 NSCLC cohorts.
- The study underscores the need for continuous monitoring of clinical outcomes and management costs in routine oncology.
- Findings highlight evolving treatment patterns and their economic implications in NSCLC care.
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