HPV-16-Induced Squamous Cell Carcinoma in Hidradenitis Suppurativa: HPV Vaccination May Be Useful

Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease associated with significant morbidity. Although cutaneous squamous cell carcinoma (cSCC) is a rare complication, it has serious consequences, particularly when associated with high-risk human papillomavirus (HPV) infections. This study examines two cases of HPV-16-induced cSCC in patients with long-standing HS and explores the potential role of HPV vaccination in preventing such malignancies.

We report on two male patients with severe HS (Hurley stage III) and cutaneous squamous cell carcinoma with positive detection of HPV DNA in the tumour tissue.

HPV vaccination may offer a preventive approach to cSCC in HS patients by reducing high-risk HPV infections. Incorporating vaccination into the management of HS, particularly in high-risk individuals, could potentially reduce the incidence of malignant transformation and improve long-term outcomes. Further research is warranted to validate these findings and refine prevention strategies.