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Related Experiment Videos

Calcium absorption and achlorhydria.

R R Recker

    The New England Journal of Medicine
    |July 11, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Calcium absorption is impaired in achlorhydria patients when taking calcium carbonate supplements on an empty stomach. Consuming calcium carbonate with meals normalizes absorption, suggesting dietary adjustments for older individuals.

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    Area of Science:

    • Gastroenterology and Nutrition
    • Mineral Metabolism

    Background:

    • Achlorhydria, a condition of low stomach acid, is suspected to impair calcium absorption.
    • Calcium carbonate is a common dietary supplement, but its efficacy in achlorhydric individuals is unclear.

    Purpose of the Study:

    • To compare calcium absorption from carbonate versus citrate forms in patients with achlorhydria and healthy controls.
    • To evaluate the impact of meal consumption on calcium carbonate absorption in achlorhydria.

    Main Methods:

    • A double-isotope method was used to measure fractional calcium absorption.
    • 11 fasting patients with achlorhydria and 9 fasting normal subjects participated.
    • Calcium absorption was assessed using calcium carbonate and pH-adjusted calcium citrate.

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    Main Results:

    • Calcium absorption from carbonate was significantly lower in achlorhydric patients (0.042) compared to normal subjects (0.225).
    • Calcium absorption from citrate was higher in achlorhydric patients (0.452) than in normal subjects (0.243).
    • Calcium carbonate absorption normalized in achlorhydric patients when taken with a meal.

    Conclusions:

    • Calcium carbonate absorption is significantly impaired in achlorhydria under fasting conditions.
    • Calcium citrate demonstrates effective calcium absorption in achlorhydric individuals.
    • Calcium carbonate may not be the optimal calcium supplement for the elderly, who commonly have achlorhydria.