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Neural Activity for Uninvolved Knee Motor Control After ACL Reconstruction Differs from Healthy Controls.

Meredith Chaput¹, Cody R Criss², James A Onate³

¹Division of Physical Therapy, School of Kinesiology and Rehabilitation Sciences, College of Health Professions and Sciences, University of Central Florida, Orlando, FL 32816, USA.

|February 26, 2025

Summary

This summary is machine-generated.

Anterior cruciate ligament reconstruction (ACLR) leads to greater neural activity in the uninvolved limb's brain regions. This suggests increased cognitive demand and potential neuromuscular deficits, challenging the use of the uninvolved limb as a clinical reference.

Keywords:

cognition fMRI knee motor control neurocognition

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Area of Science:

Neuroscience
Orthopedics
Rehabilitation Medicine

Background:

Anterior cruciate ligament reconstruction (ACLR) causes bilateral adaptations, but neural adaptations in the uninvolved limb are not well understood.
Current neurophysiologic studies often focus on the injured knee, limiting insight into whole-body neural changes post-ACLR.

Purpose of the Study:

To investigate differences in neural activity during motor control of the uninvolved limb in individuals after ACLR compared to healthy controls.
To explore potential cognitive demands associated with uninvolved limb function post-ACLR.

Main Methods:

Functional magnetic resonance imaging (fMRI) was used to assess neural activity in 15 individuals post-ACLR and 15 matched healthy controls.
Participants performed a right (uninvolved) knee flexion-extension task while undergoing fMRI scans.

Main Results:

The ACLR group exhibited significantly greater neural activity in the left middle frontal gyrus (MFG) compared to the control group.
This finding suggests altered brain activation patterns during motor control of the uninvolved limb following ACLR.

Conclusions:

Uninvolved limb motor control after ACLR may involve increased cognitive processing, indicating potential neuromuscular deficits.
These findings challenge the clinical use of the uninvolved limb as a symmetrical reference point due to potential whole-brain alterations.