Interstitial Lung Abnormalities: Unraveling the Journey from Incidental Discovery to Clinical Significance

Interstitial lung abnormalities (ILAs) are incidental radiologic abnormalities on chest computed tomography (CT) examination performed on people in whom interstitial lung disease (ILD) is not suspected. Despite the fact that most of these individuals are asymptomatic, ILAs are not synonymous with subclinical ILD, as a subset of them have symptoms and lung function impairment. On the other hand, not all ILAs progress to clinically significant ILD. Specific imaging features and patterns have been proven more likely to progress, while some individuals may comprise a higher risk group for progression. Numerous studies have demonstrated that ILAs are not only associated with an increased risk of progression toward pulmonary fibrosis and fibrosis-related mortality but are also linked to a greater incidence of lung cancer and a higher rate of all-cause mortality. Considering that the systematic evaluation of large cohorts has shown a prevalence of ILAs up to 7% and that the natural history of ILAs is unclear, successful screening and appropriate monitoring of ILAs is of particular significance for earlier diagnosis, risk factor modification, and treatment. The present review aims to summarize the current knowledge on ILAs and highlight the need to define those at greatest risk of progression to ILD and worse clinical outcomes.