Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Urinary Bladder01:23

Urinary Bladder

The urinary bladder is a hollow, muscular sac that temporarily stores urine before it is expelled from the body. It can hold approximately 600 mL of urine prior to micturition. The bladder is retroperitoneal and located behind the pubic symphysis in the pelvic floor.
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Electrostriction-driven phase instability enables giant pseudo-piezoelectricity in Hf<sub>0.5</sub>Zr<sub>0.5</sub>O<sub>2X</sub>.

Science advances·2026
Same author

Developing species-specific welfare scoresheets for the African Turquoise Killifish.

Scientific reports·2026
Same author

Perioperative management of antithrombotic therapy in elderly patients undergoing elective ACDF: implementation and outcomes of a standardized institutional protocol.

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·2026
Same author

Neurosurgeons in Italy: results of a national census (2022-2024).

Journal of neurosurgical sciences·2026
Same author

An Integrated Approach to Evaluate the Influence of Dietary <i>Olea europaea</i> L. Polyphenols on Physiological Stress, Intestinal Morphofunctional Traits, and Meat Quality in Neroametà Pigs: A Preliminary Study.

Animals : an open access journal from MDPI·2026
Same author

Perioperative Management of Chronic Subdural Hematoma Under Antithrombotic Therapy: A Multicenter Analysis of 679 Patients.

Neurosurgery·2026

Related Experiment Video

Updated: Jun 14, 2026

The Use of Cystometry in Small Rodents: A Study of Bladder Chemosensation
08:08

The Use of Cystometry in Small Rodents: A Study of Bladder Chemosensation

Published on: August 21, 2012

22.5K

Well-Preserved Urinary Bladder Anatomy in Rats After Minimally Invasive Surgery.

Daniela Giaquinto1, Antonio Palladino2, Annunziata Cummaro3,4

  • 1Department of Veterinary Medicine and Animal Production, University of Naples Federico II, I-80137 Napoli, Italy.

Biomedicines
|February 26, 2025
PubMed
Summary

This study introduces a refined surgical rat model for testing antimicrobial catheters, preserving organ microarchitecture and animal welfare. The model successfully monitored catheter-associated urinary tract infections without causing distress.

Keywords:
animal modelsantibiotic resistanceantimicrobial coatingcatheterslaboratory animalsmedical deviceurinary bladder microarchitecture

More Related Videos

Evaluation of Biomaterials for Bladder Augmentation using Cystometric Analyses in Various Rodent Models
10:19

Evaluation of Biomaterials for Bladder Augmentation using Cystometric Analyses in Various Rodent Models

Published on: August 9, 2012

19.2K
Surgical Model for Single-Staged Tissue-Engineered Urothelial Tubes in Minipigs
04:05

Surgical Model for Single-Staged Tissue-Engineered Urothelial Tubes in Minipigs

Published on: July 5, 2024

236

Related Experiment Videos

Last Updated: Jun 14, 2026

The Use of Cystometry in Small Rodents: A Study of Bladder Chemosensation
08:08

The Use of Cystometry in Small Rodents: A Study of Bladder Chemosensation

Published on: August 21, 2012

22.5K
Evaluation of Biomaterials for Bladder Augmentation using Cystometric Analyses in Various Rodent Models
10:19

Evaluation of Biomaterials for Bladder Augmentation using Cystometric Analyses in Various Rodent Models

Published on: August 9, 2012

19.2K
Surgical Model for Single-Staged Tissue-Engineered Urothelial Tubes in Minipigs
04:05

Surgical Model for Single-Staged Tissue-Engineered Urothelial Tubes in Minipigs

Published on: July 5, 2024

236

Area of Science:

  • Biomedical Engineering
  • Veterinary Surgery
  • Infectious Diseases

Background:

  • Maintaining anatomical and microarchitectural integrity is crucial for translatable experimental results.
  • Refinement strategies in animal studies are essential for ethical and legal compliance, reducing procedure severity.
  • Preclinical testing of antimicrobial and antibiofilm peptide-coated catheters requires robust animal models.

Purpose of the Study:

  • To describe a refined surgical rat model for evaluating functionalized catheters.
  • To assess the efficacy of peptide-coated catheters in preventing catheter-associated urinary tract infections (CAUTIs).
  • To ensure animal welfare and data translatability through optimized peri-operative and post-operative care.

Main Methods:

  • Utilized a refined surgical technique placing catheters in the bladder lumen, avoiding urethral placement.
  • Employed ultrasound imaging for device positioning confirmation and ultrasound-guided cystocentesis for sterile urine collection.
  • Monitored hematological and biochemical parameters, alongside clinical scores, throughout the 7- and 14-day observation periods.

Main Results:

  • No signs of distress or disease were observed in any experimental group.
  • Histological analysis of urinary bladders showed preserved anatomical structure and urothelium microarchitecture.
  • Biochemical analyses confirmed the absence of significant inflammatory infiltration.

Conclusions:

  • The described model offers a refined strategy for preclinical CAUTI research.
  • It successfully preserves bladder morphology and urothelium integrity, ensuring animal welfare.
  • The model enables effective monitoring of UTIs via sterile urine collection in long-term experiments.