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Related Concept Videos

Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

384
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
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Glaucoma: Overview01:25

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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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Angle Closure Glaucoma: Treatment01:28

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Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
426

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Related Experiment Video

Updated: May 25, 2025

Retinal Vascular Reactivity as Assessed by Optical Coherence Tomography Angiography
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Refining Glaucoma Management: Korean Population-Specific Findings from Visual Field and Optical Coherence Tomography

Sun Jung Lee1, Sung Hun Jang2, Jae Kyung Kim1

  • 1Department of Biomedical Laboratory Science, College of Health and Welfare, Dankook University, Cheonan-si 31116, Republic of Korea.

Biomedicines
|February 26, 2025
PubMed
Summary

Age and sex impact glaucoma progression, with males showing faster decline. Optical coherence tomography (OCT) and visual field tests reveal age-related changes, informing personalized Korean glaucoma management.

Keywords:
Koreaganglion cell–inner plexiform layeroptical coherence testretinal nerve fiber layervisual field test

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Area of Science:

  • Ophthalmology
  • Medical Diagnostics

Background:

  • Establishing glaucoma evaluation standards requires understanding demographic influences.
  • Korean glaucoma patient data is essential for tailored diagnostic and management protocols.

Purpose of the Study:

  • To analyze visual field tests and optical coherence tomography (OCT) results in Korean patients.
  • To determine the correlation between glaucoma test results and patient demographics (age, sex).
  • To provide a reference for establishing Korean glaucoma evaluation standards.

Main Methods:

  • Analysis of 1510 visual field tests and 1337 OCT tests from a national hospital in Seoul.
  • Utilized Humphrey automated visual field testing and OCT measurements.
  • Classified glaucoma stages (early, moderate, advanced) based on mean deviation (MD) values and performed statistical analyses.

Main Results:

  • Visual field index and MD values decreased with age in both sexes, more significantly in males.
  • Optical coherence tomography (OCT) showed age-related thinning of the ganglion cell-inner plexiform layer (GCIPL) and retinal nerve fiber layer (RNFL).
  • Females maintained thicker GCIPL and RNFL compared to males until their 60s.

Conclusions:

  • Age and sex are associated with glaucoma progression.
  • Findings support the combined use of visual field testing and OCT for glaucoma diagnosis in Korea.
  • Highlights the importance of early detection and personalized treatment for effective glaucoma management in the Korean population.