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Related Concept Videos

Neuroplasticity01:01

Neuroplasticity

267
Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.
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Long-term Potentiation01:35

Long-term Potentiation

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Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
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Long-term Depression01:03

Long-term Depression

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Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
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Brain Imaging01:14

Brain Imaging

203
Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
203
Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

696
In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
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Related Experiment Video

Updated: May 25, 2025

Assessment of Ultrastructural Neuroplasticity Parameters After In Utero Transduction of the Developing Mouse Brain and Spinal Cord
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Hallmarks of Brain Plasticity.

Yauhen Statsenko1,2, Nik V Kuznetsov1, Milos Ljubisaljevich1,3

  • 1ASPIRE Precision Medicine Institute in Abu Dhabi, United Arab Emirates University, Al Ain P.O. Box 15551, United Arab Emirates.

Biomedicines
|February 26, 2025
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Summary

Brain plasticity, the brain's ability to adapt, involves molecular changes. Non-coding RNAs (ncRNAs) are key regulators, offering potential for new neurological disease diagnostics and therapies.

Keywords:
RNA diagnosticsRNA therapeuticsbrain homeostasisbrain plasticitymolecular biomarkersncRNAtranscriptomics

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Area of Science:

  • Neuroscience
  • Molecular Biology
  • Genetics

Background:

  • Cerebral plasticity is the brain's capacity to change and adapt, crucial for learning and development.
  • It involves genetic and environmental factors, leading to structural and functional brain changes like neurogenesis and synaptic remodeling.
  • Understanding plasticity's molecular underpinnings is vital for assessing neurological disease progression and patient recovery potential.

Purpose of the Study:

  • To review the association between cerebral plasticity, its homeostasis, and non-coding RNAs (ncRNAs).
  • To highlight ncRNAs as potential targets for novel RNA-based diagnostics and therapeutics in neurological disorders.
  • To explore how new insights into brain plasticity can improve functional recovery after brain damage.

Main Methods:

  • Literature review focusing on studies linking cerebral plasticity and ncRNAs.
  • Analysis of the role of ncRNAs, particularly microRNAs, in gene regulation within the brain.
  • Synthesis of current knowledge on the implications of ncRNAs for neurological disease and rehabilitation.

Main Results:

  • Non-coding RNAs (ncRNAs), including microRNAs, are intricately linked with neurological disorders and brain plasticity.
  • These ncRNAs play a significant role in regulating gene expression relevant to brain adaptation and repair.
  • The molecular characteristics of ncRNAs offer promising avenues for developing targeted RNA-based diagnostic and therapeutic strategies.

Conclusions:

  • ncRNAs represent a critical link between brain plasticity, homeostasis, and neurological disease.
  • Targeting ncRNAs holds significant potential for advancing diagnostics and developing innovative RNA-based therapies for neurological conditions.
  • Further research into the pathophysiological mechanisms of brain plasticity at multiple levels will enhance rehabilitation strategies and patient outcomes.